Preimplantation genetic testing for aneuploidy on previously cryopreserved unbiopsied blastocysts: a cohort study in women with IVF pregnancy loss.

ABSTRACT:

Research question

Does preimplantation genetic testing for aneuploidy (PGT-A) on cryopreserved unbiopsied blastocysts improve pregnancy outcomes for women with previous IVF-related pregnancy loss?

Methods

This retrospective observational study included women who underwent vitrified blastocyst warming procedures, with or without trophectoderm biopsy for PGT-A, between January 2016 and June 2023. Participants had experienced two or more clinical pregnancy losses, with at least one loss following in vitro fertilization (IVF). The primary outcome was the cumulative live birth/ongoing pregnancy rate, analyzed using generalized estimating equations (GEE) with confounding adjustments.

Results

The cohort included 146 women, comprising 72 who intended to pursue PGT-A on thawed

SUBMITTER: Cai H 

PROVIDER: S-EPMC11874781 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature