A public, cross-reactive glycoprotein epitope confounds Ebola virus serology.

ABSTRACT: Ebola disease (EBOD) in humans is a severe disease caused by at least four related viruses in the genus Orthoebolavirus, most often by the eponymous Ebola virus. Due to human-to-human transmission and incomplete success in treating cases despite promising therapeutic development, EBOD is a high priority in public health research. Yet despite almost 50 years since EBOD was first described, the sources of these viruses remain undefined and much remains to be understood about the disease epidemiology and virus emergence and spread. One important approach to improve our understanding is detection of antibodies that can reveal past human infections. However, serosurveys routinely describe seroprevalences that imply infection rates much higher than those clinically observed. Proposed hypotheses

SUBMITTER: Kainulainen MH 

PROVIDER: S-EPMC11874798 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature