A novel prognostic model utilizing TMTV and SUVmax from ¹⁸F-FDG PET/CT for predicting overall survival in patients with extranodal NK/T- cell lymphoma.

ABSTRACT:

Background

Survival prediction accuracy of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) in extra-nodal natural killer/T-cell lymphoma (ENKTL) is controversial. This study aimed to evaluate the prognostic value of ¹⁸F-FDG PET/CT parameters including maximum standardized uptake value (SUVmax), total metabolic tumor volume (TMTV) and total lesion glycolysis (TLG), and to develop a new prognostic model for ENKTL.

Methods

We analyzed 390 ENKTL patients with comprehensive clinical and survival data. All patients received asparaginase-based chemotherapy with or without radiotherapy, or radiotherapy alone. Metabolic tumor volume (MTV) was calculated using a 41% SUVmax threshold, and TLG was computed as MTV mul

SUBMITTER: Wang H 

PROVIDER: S-EPMC11874801 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature