The role of vitamin D deficiency in placental dysfunction: A systematic review.

ABSTRACT:

Introduction

Vitamin D plays a critical role in pregnancy, supporting placental function via angiogenesis, immune regulation, and nutrient transport. Deficiency in vitamin D during gestation is associated with complications such as preeclampsia, intrauterine growth restriction (IUGR), and preterm birth. However, the mechanisms linking vitamin D deficiency to placental dysfunction remain inadequately understood, highlighting the need for systematic evaluation.

Methods

A systematic review was conducted in adherence to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, with searches in PubMed, Scopus, and Web of Science for studies published within the last 20 years. Inclusion criteria targeted human studies examining the association between

SUBMITTER: Gerovasili E 

PROVIDER: S-EPMC11874864 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature