Development and validation of a nomogram predicting multidrug-resistant tuberculosis risk in East China.

ABSTRACT:

Objective

Multidrug-resistant tuberculosis (MDR-TB) is a global health threat. Our study aimed to develop and externally validate a nomogram to estimate the probability of MDR-TB in patients with TB.

Methods

A total of 453 patients with TB in Anhui Chest Hospital between January 2019 and December 2020 were included in the training cohort. In addition, 116 patients with TB from Anhui Provincial Hospital Infection District between January 2015 and November 2023 were included in the validation cohort. Multivariable logistic regression analysis was applied to build a predictive model by combining the feature selected in the least absolute shrinkage and selection operator regression model. The C-index, calibration plot, and decision curve analysis were implemented to evalu

SUBMITTER: He F 

PROVIDER: S-EPMC11874934 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature