Interactive visualization and interpretation of pangenome graphs by linear reference-based coordinate projection and annotation integration.

ABSTRACT: With the increasing availability of high-quality genome assemblies, pangenome graphs emerged as a new paradigm in the genomic field for identifying, encoding, and presenting genomic variation at both the population and species level. However, it remains challenging to truly dissect and interpret pangenome graphs via biologically informative visualization. To facilitate better exploration and understanding of pangenome graphs toward novel biological insights, here we present a web-based interactive visualization and interpretation framework for linear reference-projected pangenome graphs (VRPG). VRPG provides efficient and intuitive support for exploring and annotating pangenome graphs along a linear-genome-based coordinate system (e.g., that of a primary linear reference genome). Moreover,

SUBMITTER: Miao Z 

PROVIDER: S-EPMC11874961 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature