Proxy panels enable privacy-aware outsourcing of genotype imputation.

ABSTRACT: One of the major challenges in genomic data sharing is protecting participants' privacy in collaborative studies and in cases when genomic data are outsourced to perform analysis tasks, for example, genotype imputation services and federated collaborations genomic analysis. Although numerous cryptographic methods have been developed, these methods may not yet be practical for population-scale tasks in terms of computational requirements, rely on high-level expertise in security, and require each algorithm to be implemented from scratch. In this study, we focus on outsourcing of genotype imputation, a fundamental task that utilizes population-level reference panels, and develop protocols that rely on using "proxy panels" to protect genotype panels, whereas the imputation task is being outso

SUBMITTER: Zhi D 

PROVIDER: S-EPMC11874966 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature