Characterization of Humoral Responses to Nipah Virus Infection in the Syrian Hamster Model of Disease.

ABSTRACT: Nipah virus (NiV) is a highly pathogenic paramyxovirus. The Syrian hamster model recapitulates key features of human NiV disease and is a critical tool for evaluating antivirals and vaccines. Here we describe longitudinal humoral immune responses in NiV-infected Syrian hamsters. Samples were obtained 1-28 days after infection and analyzed by ELISA, neutralization, and Fc-mediated effector function assays. NiV infection elicited robust antibody responses against the nucleoprotein and attachment glycoprotein. Levels of neutralizing antibodies were modest and only detectable in surviving animals. Fc-mediated effector functions were mostly observed in nucleoprotein-targeting antibodies. Antibody levels and activities positively correlated with challenge dose.

SUBMITTER: Scholte FEM 

PROVIDER: S-EPMC11875002 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature