Evaluation of Serum and Aqueous Humor Neurofilament Light Chain as Markers of Neurodegeneration in Glaucoma.

ABSTRACT:

Purpose

The purpose of this study was to evaluate the relationship between serum and aqueous humor (AH) neurofilament light chain (NfL) and to determine whether serum NfL is elevated in patients undergoing ocular surgery who have glaucoma compared with those who do not.

Methods

In this single-center, case-control study, we enrolled patients with various types and stages of glaucoma undergoing planned ophthalmic surgery as part of their routine care and compared them with patients without glaucoma undergoing phacoemulsification for age-related cataract. We recruited 110 patients with glaucoma and 113 patients without glaucoma and collected AH and blood from these participants. Levels of AH and serum NfL were quantified using the Single-Molecule Array (Simoa) NF-light assay (Q

SUBMITTER: Lin JB 

PROVIDER: S-EPMC11875033 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature