Multimeric, multivalent fusion carrier proteins for site-selective glycoconjugate vaccines simultaneously targeting <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i>.

ABSTRACT: Staphylococcus aureus and Pseudomonas aeruginosa are major antimicrobial-resistant pathogens that often synergize in polymicrobial infections, such as chronic wound infections. These notorious and increasingly resistant bacteria contribute significantly to reduced antibiotic efficacy. Despite their substantial clinical burden, the urgent need to combat bacterial resistance and extensive research efforts, no vaccines currently exist for either bacterium. Glycoconjugate vaccines, which extend the range of suitable vaccine antigens to bacterial carbohydrates, could play a major role in this emergence. This study introduces a multiepitope vaccine conjugating S. aureus capsular polysaccharide serotype 8 to a chimeric protein fusing Hla and PcrV, two potent cytotoxins from <

SUBMITTER: Sorieul C 

PROVIDER: S-EPMC11875126 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature