Racial variability in immune responses only partially explains differential systemic sclerosis disease severity.

ABSTRACT:

Objective

To understand if autoantibodies account for racial variation in disease severity, we compared autoantibody distribution and associated phenotype between self-identified black and white systemic sclerosis (SSc) patients.

Methods

803 black and 2178 white SSc patients had systematic testing for autoantibodies using Euroimmun (centromere (ACA), RNA-polymerase III (POLR3), Scl70, PM/Scl, NOR90, Th/To, Ku, U3RNP and Ro52) and commercial ELISA (U1RNP). In this observational study, logistic regression was performed to assess the association between self-identified race and outcomes, adjusting for autoantibodies. To estimate whether the effect of race was mediated by autoantibody status, race coefficients from multivariate models including and excluding autoantibodies were

SUBMITTER: Kuchinad KE 

PROVIDER: S-EPMC11875133 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature