Potential association between magnesium depletion score and hyperuricemia in American adults, a cross-sectional study based on NHANES 2003-2018.

ABSTRACT:

Objective

The pathophysiological mechanisms underlying hyperuricemia necessitate the identification of contributing factors to better understand disease progression and develop effective therapies. This study aimed to investigate the association between Magnesium Depletion Score (MDS) and hyperuricemia.

Methods

A cross-sectional study was sourced from the National Health and Nutrition Examination Survey 2003-2018. Hyperuricemia was defined by serum uric acid levels. MDS was calculated by incorporating factors affecting renal magnesium reabsorption.Weighted multivariable logistic regression was employed to assess the association between MDS and hyperuricemia, with sensitivity analyses to confirm robustness. Additionally, Restricted Cubic Spline (RCS) and Receiver Operating Ch

SUBMITTER: Li Z 

PROVIDER: S-EPMC11875140 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature