A map of glycation and glycoxidation sites in collagen I of human cortical bone: Effects of sex and type 2 diabetes.

ABSTRACT: Complications of diabetes is a major health problem affecting multiple organs including bone, where the chronic disease increases the risk of fragility fractures. One hypothesis suggests a pathogenic role for hyperglycemia-induced modification of proteins, a.k.a. advanced glycation end products (AGEs), resulting in structural and functional damage to bone extracellular matrix (ECM). Evidence supporting this hypothesis has been limited by the lack of comprehensive information about the location of AGEs that accumulate in vivo at specific sites within the proteins of bone ECM. Analyzing extracts from cortical bone of cadaveric femurs by liquid chromatography tandem mass spectrometry, we generated a quantitative AGE map of human collagen I for male and female adult donors with and without dia

SUBMITTER: Voziyan P 

PROVIDER: S-EPMC11875209 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature