Estrogen-Related Receptor is Required in Adult <i>Drosophila</i> Females for Germline Stem Cell Maintenance.

ABSTRACT: Stem cell self-renewal and proper tissue function rely on conserved metabolic regulators to balance energy production with inter-organ metabolic trafficking. The estrogen-related receptor (ERR) subfamily of orphan nuclear receptors are major transcriptional regulators of metabolism. In mammals, ERRs have roles in regulating mitochondrial biosynthesis, lipid metabolism, as well as stem cell maintenance. The sole Drosophila ERR ortholog promotes larval growth by establishing a metabolic state during the latter half of embryogenesis. In addition, ERR is required in adult Drosophila males to coordinate glycolytic metabolism with lipid synthesis and within the testis to regulate spermatogenesis gene expression and fertility. Despite extensive work characterizing of the role

SUBMITTER: Zike AB 

PROVIDER: S-EPMC11875244 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature