Mendelian randomization analyses uncover causal relationships between brain structural connectome and risk of psychiatric disorders.

ABSTRACT: Growing evidence suggests abnormalities of brain structural connectome in psychiatric disorders, but the causal relationships remain underexplored. We conducted bidirectional two-sample Mendelian randomization (MR) analyses to investigate the causal links between 206 white-matter connectivity phenotypes (n = 26,333, UK Biobank) and 13 major psychiatric disorders (n = 14,307 to 1,222,882). Forward MR analyses identified causal effects of genetically predicted five white-matter structural connectivity phenotypes on six psychiatric disorders, with associations being significant or suggestive. For instance, structural connectivity between the left-hemisphere frontoparietal control network and right-hemisphere default mode network was significantly negatively associated with autism spectrum dis

SUBMITTER: Xiao K 

PROVIDER: S-EPMC11875323 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature