Association of cognitive and structural correlates of brain aging and incident epilepsy. The Framingham Heart Study.

ABSTRACT:

Objectives

Late-onset epilepsy has the highest incidence among all age groups affected by epilepsy and often occurs in the absence of known clinical risk factors such as stroke and dementia. There is increasing evidence that brain changes contributing to epileptogenesis likely start years before disease onset, and we aim to relate cognitive and imaging correlates of subclinical brain injury to incident late-onset epilepsy in a large, community-based cohort.

Methods

We studied Offspring Cohort of the Framingham Heart Study participants 45 years or older, who were free of prevalent stroke, dementia, or epilepsy, and had neuropsychological (NP) evaluation and brain magnetic resonance imaging (MRI). Cognitive measures included Visual Reproduction Delayed Recall, Logical Memory D

SUBMITTER: Stefanidou M 

PROVIDER: S-EPMC11875459 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature