Hydrophobic Domain Modulation of Chemical Responsiveness in a Bolaamphiphile-Based Supramolecular Monomer.

ABSTRACT: Self-immolative chemistries that respond in an irreversible manner to external stimuli are highly attractive to permanently degrade filamentous supramolecular biomaterials. Within the monomer, a balance needs to be struck between its capacity to be supramolecularly polymerized and degraded at an appropriate rate for a given application. Herein, we unravel the structure-property-function relationships of a library of squaramide-based bolaamphiphiles bearing a central disulfide-based self-immolative spacer to construct supramolecular polymers responsive to chemical stimuli in aqueous solutions. We examine the impact of changing the alkyl domain length (2 to 12 methylene units) on the formation of supramolecular filaments and their rate of degradation in response to a biological antioxidant,

SUBMITTER: Vittala SK 

PROVIDER: S-EPMC11875559 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature