Molecular Insights into the Heme-Binding Potential of Plant NCR247-Derived Peptides.

ABSTRACT: Heme is involved in many critical processes in pathogenic bacteria as iron acquisition by these microorganisms is achieved by either direct uptake of heme or use of heme-binding proteins called hemophores. Exploring the underlying mechanisms on a molecular level can open new avenues in understanding the host-pathogen interactions. Any imbalance of the heme concentration has a direct impact on the bacterial growth and survival. Thus, heme-regulated proteins that are involved in heme homeostasis poise to be promising targets for research. Similarly, naturally occurring compounds, including cysteine-rich peptides from either plant secondary metabolites or venom toxins from vertebrates and invertebrates, have been studied for their therapeutic potential. NCR247 is such a cysteine-rich peptide,

SUBMITTER: Vaidya SM 

PROVIDER: S-EPMC11875561 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature