Causal relationship between uterine fibroids and cardiovascular disease: A two-sample Mendelian randomization study.

ABSTRACT: Previous studies have indicated that patients with uterine fibroids (UF) may have an elevated risk of cardiovascular disease (CVD), although the causal relationship between UF and CVD remains unclear. In this Mendelian randomization (MR) study, we aimed to investigate the causal association between genetic susceptibility to UF and the risk of developing CVD. We extracted summary statistics for single nucleotide polymorphisms associated with UF and 5 CVDs from multiple databases for further analysis. First, we used linkage disequilibrium score regression to assess the genetic correlation across the genome. Next, we performed univariate MR (UVMR), and to ensure the robustness of our results, we conducted sensitivity analyses using several methods. Additionally, we applied multivariable MR (M

SUBMITTER: Cui J 

PROVIDER: S-EPMC11875593 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature