Comparison of Tranexamic Acid Administration Methods in Rhytidectomy: A Prospective, Randomized, Double-blind Study.

ABSTRACT:

Background

Tranexamic acid (TXA) is an antifibrinolytic agent with promising benefits in facial rejuvenation surgery. The best way to administer this medication for therapeutic value is currently unknown. This study compared outcomes for facelift patients given TXA intravenously versus locally in tumescent solution.

Methods

Sixty rhytidectomy patients were randomized to receive 1 g of TXA intravenously or 150 mg of TXA in facial tumescent. Blood loss and surgeon-assigned bleeding rate were recorded intraoperatively for each side of the face. On postoperative day 7, patients assessed surgical satisfaction and bruising and swelling levels, and the surgeon graded ecchymosis and edema. Time to drain removal and complication incidence were also documented.

Results

Mean blo

SUBMITTER: Davison SP 

PROVIDER: S-EPMC11875600 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature