Thoracoabdominal Normothermic Regional Perfusion: Real-world Experience and Outcomes of DCD Liver Transplantation.

ABSTRACT:

Background

Donation after circulatory death liver transplantation (DCD LT) is underused given historical outcomes fraught with ischemic cholangiopathy (IC). We aimed to assess 6-mo IC in LT from DCD via normothermic regional perfusion (NRP) compared with DCD via static cold storage (SCS).

Methods

A retrospective review of adult Maastricht-III DCD liver donors and recipients at the University of Colorado Hospital from January 1, 2017, to August 27, 2024, was performed. The 6-mo IC rate was compared between NRP and SCS. Secondary outcomes included biochemical assessments of accepted versus declined NRP liver allografts and allograft and patient survival for NRP and SCS groups.

Results

One hundred sixty-two DCD LTs (SCS = 79; NRP = 97) were performed and 150 recipients (

SUBMITTER: Bababekov YJ 

PROVIDER: S-EPMC11875611 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature