The role of gut microbiota and plasma metabolites in ulcerative colitis: Insights from Mendelian randomization analysis.

ABSTRACT: Emerging research suggests that alterations in gut microbiota composition may play a significant role in the pathogenesis of ulcerative colitis (UC). Plasma metabolites, which are influenced by gut microbiota, have also been implicated, but their role in UC remains unclear. This study aims to determine whether specific plasma metabolites mediate the causal relationship between gut microbiota and UC using Mendelian randomization (MR) analysis. This study employed publicly available summary-level data from genome-wide association studies and metagenomic datasets. Gut microbiota data were derived from the FINRISK cohort (5959 participants), plasma metabolite data from the Canadian Longitudinal Study on Aging (8299 individuals), and UC data from multiple consortia (17,030 cases and 883,787 con

SUBMITTER: Zheng X 

PROVIDER: S-EPMC11875619 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature