TIM-3 marks measurable residual leukemic stem cells responsible for relapse after allogeneic stem cell transplantation.

ABSTRACT: In this study, we investigated the measurable residual leukemic stem cell (MR-LSC) population after allogeneic stem cell transplantation (allo-SCT) for high-risk acute myeloid leukemia (AML), utilizing T-cell immunoglobulin mucin-3 (TIM-3) expression as a functional marker of AML leukemic stem cells (LSCs). Analysis of the CD34⁺CD38^- fraction of bone marrow cells immediately after achievement of engraftment revealed the presence of both TIM-3⁺LSCs and TIM-3^- donor hematopoietic stem cells (HSCs) at varying ratios. Genetic analysis confirmed that TIM-3⁺ cells harbored patient-specific mutations identical to those found in AML clones, whereas TIM-3^- cells did not, indicating that TIM-3⁺CD34⁺CD38^-

SUBMITTER: Sakoda T 

PROVIDER: S-EPMC11875787 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature