Establishment of cancer cell radiosensitivity database linked to multi-layer omics data.

ABSTRACT: Personalized radiotherapy based on the intrinsic sensitivity of individual tumors is anticipated, however, it has yet to be realized. To explore cancer radiosensitivity, analysis in combination with omics data is important. The Cancer Cell Line Encyclopedia (CCLE) provides multi-layer omics data for hundreds of cancer cell lines. However, the radiosensitivity counterpart is lacking. To address this issue, we aimed to establish a database of radiosensitivity, as assessed by the gold standard clonogenic assays, for the CCLE cell lines by collecting data from the literature. A deep learning-based screen of 33,284 papers identified 926 relevant studies, from which SF₂ (survival fraction after 2 Gy irradiation) data were extracted. The median SF₂ (mSF₂) was calc

SUBMITTER: Oike T 

PROVIDER: S-EPMC11875790 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature