Adjuvant endocrine treatment strategies for non-metastatic breast cancer: a network meta-analysis.

ABSTRACT:

Background

Multiple trials have evaluated escalation strategies of endocrine therapy for early breast cancer, including ovarian function suppression (OFS) and aromatase inhibitors (AI) in premenopausal patients and extended endocrine therapy. However, several aspects remain controversial due to the heterogeneity of study designs and lack of statistical power in relevant subgroups. We aimed to investigate the optimal endocrine therapy strategy.

Methods

A systematic literature search was performed and last updated in August 2024 to identify randomized controlled trials (RCT) evaluating endocrine treatment strategies for hormone receptor positive breast cancer. A network meta-analysis with a frequentist framework using random-effects model was used to pool direct and indirect e

SUBMITTER: Papakonstantinou A 

PROVIDER: S-EPMC11875833 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature