Unsymmetric Triazine-Based Triglucoside Detergents for Membrane Protein Stability.

ABSTRACT: Membrane proteins play a crucial role in a variety of biological processes and are key targets for pharmaceutical development. Structural studies of membrane proteins provide molecular insights into the mechanisms of these processes and are essential for effective drug discovery. Historically, these studies have relied on solubilization of the target protein using detergents, but conventional detergents often fail to maintain the stability of challenging membrane proteins. To address this issue, there is a need to develop novel detergents with enhanced protein stabilization properties. In this study, we synthesized unsymmetric variants of recently reported tris(hydroxymethyl)aminomethane(TRIS)-linker-bearing triazine-based triglucosides (TTGs) by incorporating two different alkyl chains (l

SUBMITTER: Ehsan M 

PROVIDER: S-EPMC11875885 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature