A Transmit-Receive Phased Array for Microbubble-Mediated Focused Ultrasound Brain Therapy in Small Animals.

ABSTRACT: Focused ultrasound (FUS) combined with circulating microbubbles (MBs) can be employed for non-invasive, localized agent delivery across the blood-brain barrier (BBB). Previous work has demonstrated the feasibility of clinical-scale transmit-receive phased arrays for performing transcranial therapies under MB imaging feedback.

Objective

This study aimed to design, construct, and evaluate a dual-mode phased array for MB-mediated FUS brain therapy in small animals.

Methods

A 256-element sparse hemispherical array (100 mm diameter) was fabricated by installing 128 PZT cylinder transmitters (f₀ = 1.16 MHz) and 128 broadband PVDF receivers within a 3D-printed scaffold.

Results

The transmit array's focal size at the geometric focus was 0.8 mm × 0.8 mm × 1.7 mm, wit

SUBMITTER: Lin Y 

PROVIDER: S-EPMC11875903 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature