Novel Self-Calibrated Threshold-Free Probabilistic Fibrosis Signature Technique for 3D Late Gadolinium Enhancement MRI.

ABSTRACT: Myocardial fibrosis is a crucial marker of heart muscle injury in several heart disease like myocardial infarction, cardiomyopathies, and atrial fibrillation (AF). Fibrosis and associated scarring (dense fibrosis) are also vital for assessing heart muscle pre- and post-intervention, such as evaluating left atrial (LA) fibrosis/scarring in patients undergoing catheter ablation for AF. Although cardiac MRI is the gold standard for fibrosis assessment, current quantification methods are unreliable due to their reliance on variable thresholding and sensitivity to MRI uncertainties, lacking standardization and reproducibility. Importantly, current methods focus solely on quantifying fibrosis volume ignoring the unique MRI characteristics of fibrosis density and unique distribution, that could b

SUBMITTER: Mehrnia M 

PROVIDER: S-EPMC11875924 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature