Leptin augments IL-13-induced airway eotaxins and submucosal eosinophilia in obesity-associated asthma.

ABSTRACT:

Background

Airway tissue eosinophilia can be an observed feature of obesity-associated type 2 (T2) asthma, but the processes mediating this inflammation are unknown.

Objective

To investigate a process whereby leptin, an adipokine elevated in obesity, potentiates pulmonary eosinophilia and eotaxin production by airway fibroblasts in T2 asthma.

Methods

We assessed associations between body mass index and airway eosinophilia as well as leptin and eotaxin production in 82 participants with asthma, 37 of whom exhibited obesity. Cultured human airway fibroblasts and mouse models of chronic allergic airway disease were used to evaluate leptin's effect on eotaxin production and lung eosinophilia. The role of IL-13 receptor alpha 2 (IL-13Rα2) in mediating these processes was e

SUBMITTER: Ingram JL 

PROVIDER: S-EPMC11875949 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature