PIN1 Prolyl Isomerase Promotes Initiation and Progression of Bladder Cancer through the SREBP2-Mediated Cholesterol Biosynthesis Pathway.

ABSTRACT:

Significance

This study provides deeper insights into the regulatory role of the phospho-dependent prolyl isomerase PIN1 in bladder cancer. The identification of the link between PIN1 and SREBP2-mediated transcription and cholesterol biosynthesis offers the potential for developing novel therapeutic strategies for bladder cancer.

SUBMITTER: Wang X 

PROVIDER: S-EPMC11875963 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature