PET Mapping of Receptor Occupancy Using Joint Direct Parametric Reconstruction.

ABSTRACT: Receptor occupancy (RO) studies using PET neuroimaging play a critical role in the development of drugs targeting the central nervous system (CNS). The conventional approach to estimate drug receptor occupancy consists in estimation of binding potential changes between two PET scans (baseline and post-drug injection). This estimation is typically performed separately for each scan by first reconstructing dynamic PET scan data before fitting a kinetic model to time activity curves. This approach fails to properly model the noise in PET measurements, resulting in poor RO estimates, especially in low receptor density regions.

Objective

In this work, we evaluate a novel joint direct parametric reconstruction framework to directly estimate distributions of RO and other kinetic parameters

SUBMITTER: Marin T 

PROVIDER: S-EPMC11875991 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature