Antibacterial Activity of a Linolenic Acid Stigmasterol Ester Produced by Lipase-Mediated Transesterification.

ABSTRACT: Phytosterols are naturally found in lipid-rich plant foods and oils. These compounds exhibit various pharmacological effects, including anti-inflammatory, antimicrobial, antioxidant, and cholesterol-lowering properties. However, their industrial application has been limited due to their high melting points and poor solubility in both water and oil. Some unsaturated fatty acids can enhance phytosterols' oil solubility while exhibiting antimicrobial activities against various bacterial strains. In this study, we synthesized a linolenic acid stigmasterol ester (LASE) to improve oil and emulsion solubility of stigmasterol, a phytosterol known for its beneficial physiological effects in humans. LASE was synthesized with Candida antarctica lipase A through a transesterification reaction u

SUBMITTER: Kim YA 

PROVIDER: S-EPMC11876018 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature