Effect of sex, pubertal stage, body mass index, oral contraceptive use, and C-reactive protein on vitamin D binding protein reference values.

ABSTRACT:

Objective

Vitamin D binding protein (DBP) regulates the transport and availability of vitamin D. We aimed to establish age- and sex-specific reference ranges for serum concentrations of DBP in healthy infants, children, and adolescents. In addition, we investigated DBP's associations with age, sex, puberty, body mass index (BMI), and oral contraceptive use.

Design and methods

2,503 serum samples from children and adolescents aged 3 months to 17 years from the LIFE Child cohort were analyzed to study DBP levels in this population (49.3% female subjects, 50.7% male subjects). Age- and sex-dependent reference percentiles were established using generalized additive models. We used linear mixed effects models to assess DBP's associations with age, sex, pubertal status, the BMI st

SUBMITTER: von Heimburg P 

PROVIDER: S-EPMC11876044 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature