Body weight in systemic lupus erythematosus is associated with disease activity and the adaptive immune system, independent of type I IFN.

ABSTRACT:

Objective

To explore the relationship between physique and immunological disturbances in systemic lupus erythematosus (SLE), we analyzed the clinical, immunological and transcriptomic characteristics of patients with SLE in relation to body mass index (BMI).

Methods

Clinical characteristics were obtained from patient charts, and serum cytokine levels were measured. Phenotypes and transcriptomes of peripheral immune cells from patients with SLE in the ImmuNexUT database were analyzed in relation to BMI.

Results

Thirty-four SLE patients were included in the analysis. Fever and mucocutaneous symptoms were commonly observed in SLE patients with a low BMI. BMI was negatively correlated with the SLE disease activity (SLEDAI)-2K scores. Multiple regression analysis revealed

SUBMITTER: Teruya H 

PROVIDER: S-EPMC11876045 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature