Tourette syndrome and brain stimulation therapy: a systematic review and meta-analysis of current evidence.

ABSTRACT:

Background

Tourette syndrome (TS) is a neurological disorder characterized by tics, often associated with obsessive-compulsive disorder (OCD). Severe cases may require interventions such as deep brain stimulation (DBS) or repetitive transcranial magnetic stimulation (rTMS).

Methods

A thorough search was performed across PubMed/Medline, Embase, (CENTRAL), and Google Scholar. Studies comparing DBS and rTMS efficacy for TS were included if they reported YGTSS before and after treatment. Two independent reviewers screened the search results, extracted data, and assessed study quality using standardized tools.

Results

22 studies met the inclusion criteria, with a total of 222 participants. Analysis of RCTs investigating post-intervention rTMS vs baseline showed a statistic

SUBMITTER: Aloufi AK 

PROVIDER: S-EPMC11876145 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature