Vitamin K supports TGF-β1 depended <i>in vitro</i> human Langerhans cell differentiation and function via Axl.

ABSTRACT:

Introduction

On the outermost edge of the body a dense network of dendritic cells (DCs), the so-called Langerhans cells (LCs), represents the first immune barrier. The establishment and maintenance of this epidermal network is dependent on the cytokine transforming growth factor-β1 (TGF-β1) expressed by keratinocytes (KC) and LCs. We recently identified a crucial downstream effector of TGF-β1, the receptor tyrosine kinase Axl. Axl belongs to the TAM receptor family, which also includes Tyro3 and Mer, and is activated through the vitamin K-dependent ligands Gas6 and Protein S.

Methods

We have now established that TGF-β1 dependent in vitro human LC generation from CD34⁺ progenitor cells can be enhanced by Axl over-expression.

Results

Additionally, we s

SUBMITTER: Bauer T 

PROVIDER: S-EPMC11876179 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature