Prognostic value of serum lipids in newly diagnosed acute promyelocytic leukemia.

ABSTRACT:

Background and purpose

Dyslipidemia has been linked to acute promyelocytic leukemia (APL), with abnormal lipid metabolism observed during treatment. However, its role in APL pathogenesis remains unclear. This study investigates the relationship between serum lipid levels and clinical features, risk stratification, bleeding tendency, and prognosis of newly diagnosed APL patients, focusing on the role of the PTK2 gene in regulating lipid metabolism and its potential as a therapeutic target.

Materials and methods

We analyzed 90 newly diagnosed APL patients and 99 controls. Statistical analyses, including logistic regression, survival analysis, and protein-protein interaction (PPI) network, were used to assess lipid correlations with APL. Subgroup analyses explored specific clin

SUBMITTER: Wang S 

PROVIDER: S-EPMC11876187 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature