Rebound effect of hypothalamic-pituitary thyreotropic activity: a new model to better understand hypothyroidism.

ABSTRACT:

Purpose

Hypothalamic-pituitary thyrotropic activity (HPta) is crucial since TSH is the mainstay for evaluating primary hypothyroidism (hT) and replacement therapy in clinical practice. Despite TSH values, some patients experience symptoms and metabolic alterations, raising several issues about hT. The aim of the study was to investigate factors influencing the TSH values achieved after a period of hT induced in a standardized and controlled manner (TSH_time1).

Methods

Our institutional database was searched to extract records of differentiated thyroid cancer (DTC) patients undergoing a LT4 withdrawal protocol prior to radioiodine (RAI) administration. We collected clinical and biochemical parameters before LT4 discontinuation and after one month of induced hT. We performed M

SUBMITTER: Piticchio T 

PROVIDER: S-EPMC11876191 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature