Depressive symptoms and quality of life in patients with benign essential blepharospasm under long-term therapy with botulinum toxin.

ABSTRACT: Regular and long-term injections of botulinum toxin (BoNT) are considered the first line therapy for essential blepharospasm (BEB), but no data exists on the long-term effect of this therapy on depressive symptoms and quality of life. This study aims to prospectively evaluate the long-term effects of BoNT therapy on depressive symptoms as well as on daily activities, emotional well-being and quality of life using validated questionnaires (BEB-scale, Beck`s Depression Inventory (BDI)). 86 patients diagnosed with BEB were followed up for a median of 4 years. Clinical symptoms improved significantly after BoNT-injections. Everyday activities and subjective assessment of the overall situation improved gradually under long-term BoNT therapy. Significant correlations (p < 0.0001; r-values betwee

SUBMITTER: Wabbels B 

PROVIDER: S-EPMC11876193 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature