Renin-angiotensin system inhibitor use and risk of Parkinson's disease: a meta-analysis.

ABSTRACT:

Background

Hypertension is a recognized risk factor for Parkinson's disease (PD). The renin-angiotensin system (RAS) inhibitors are widely used to treat hypertension. However, the association of RAS inhibitor use with PD has still been an area of controversy.

Methods

Thus, we conducted a meta-analysis to investigate the relationship between RAS inhibitor use and PD. PUBMED and EMBASE databases were searched for articles published up to Oct 2023. All studies that examined the relationship between RAS inhibitor use and the incidence of PD were included.

Results

Seven studies with total 3,495,218 individuals met our inclusion criteria for this meta-analysis. Overall, RAS inhibitor use was associated with a reduction in PD risk (OR = 0.88, 95%CI = 0.79-0.98) compared with

SUBMITTER: Xu TX 

PROVIDER: S-EPMC11876239 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature