Metabolic, genetic and immunological features of relatives of type 1 diabetes patients with elevated insulin resistance.

ABSTRACT:

Purpose

Insulin resistance plays a pivotal role in the preclinical stages of type 1 diabetes (T1D).

Objective

This study aims at exploring the genetic, metabolic, and immunological features associated with insulin resistance among individuals at risk of developing T1D.

Methods

We retrospectively selected relatives of individuals with T1D from participants in the TrialNet Pathway to Prevention study. They were categorized into two groups: high-H (n = 27) and low-H (n = 30), based on the upper and lower quartiles of insulin resistance assessed using the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR). Genetic predisposition was determined using the T1D Genetic Risk Score 1 (GRS1). Additionally, glucose control was evaluated through an oral glucose tolerance

SUBMITTER: Codazzi V 

PROVIDER: S-EPMC11876269 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature