Predicting disease progression from the rate of bodyweight change in nasopharyngeal carcinoma patient during radiotherapy.

ABSTRACT: Bodyweight loss is a common occurrence in Nasopharyngeal Carcinoma (NPC) patients during Radiotherapy (RT). Previous studies found that the prognostic value of percentage weight loss (pWL) during RT is not credible. We aimed to develop a novel progression predictor surrogated to pWL by modelling all bodyweight records measured during the treatment interval. This retrospective study included two independent hospitals of 624 patients. The Predicted Progression Probability (PPP) was obtained from deep learning-guided differential equation solution, model by the patient's age, sex, body height, and the weekly measured bodyweight records. The performance of PPP in predicting disease progression was assessed, its association with prognosis and adjuvant chemotherapy response was evaluated. The PP

SUBMITTER: Sun J 

PROVIDER: S-EPMC11876310 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature