Pro-survival roles for p21(Cip1/Waf1) in non-small cell lung cancer.

ABSTRACT:

Background

Quiescence is reversible proliferative arrest. Multiple mechanisms regulate quiescence that are not fully understood. High expression of the CDK inhibitor p21^Cip1/Waf1 correlates with a poor prognosis in non-small cell lung cancer (NSCLC) and, in non-transformed cells, p21 promotes quiescence after replication stress. We tested whether NSCLC cells enter p21-dependent quiescence and if this is advantageous to NSCLC cells.

Methods

Through analysis of patient data and quantitative, single-cell, timelapse imaging of genetically-engineered NSCLC reporter cell lines we investigated the role of p21 in NSCLC during normal proliferation and after chemotherapy.

Results

High p21 expression correlates with a poor prognosis in TP53 wild-type, but not TP53 mut

SUBMITTER: Cutty SJ 

PROVIDER: S-EPMC11876327 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature