Fabrication of a multilayer bioabsorbable composite vascular stent utilizing oxidized starch-Fe₃O₄ nanoparticles and polycaprolactone nanofibers.

ABSTRACT: Currently, bioabsorbable polymer stents are utilized to mitigate the risk of late stent restenosis in cardiovascular applications. In this context, we propose a novel assembly that integrates polycaprolactone (PCL) nano-fibers and oxidized starch (OS) with iron oxide nanoparticles (IONPs) to create a rigid-swelling scaffold for cardiovascular stents. This study fabricates the nanocomposite (NC) using a combination of electrospinning and electrospray techniques. The stent body is formed by leveraging the self-adhesive (SA) properties of multiple NC sheets, resulting in a multilayer (ML) structure. To achieve the desired stent shape, we employed the CO₂ laser cutting method on a specific pattern after rolling the prepared sheets in two steps: OS hydration followed by melting the p

SUBMITTER: Hataminia F 

PROVIDER: S-EPMC11876349 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature