Association of prenatal trajectories of depressive and anxiety symptoms with neurodevelopment of children aged 0-24 months: A prospective study.

ABSTRACT:

Background

Prenatal depression and anxiety can significantly impact a child's neurodevelopment. However, the specific timing and patterns of these maternal psychological symptoms during pregnancy that influence the child's neurodevelopment remain unclear. This study aimed to investigate the associations of maternal depressive and anxiety symptoms across pregnancy trimesters and their trajectories with neurodevelopmental outcomes in children aged 0 to 24 months.

Methods

A total of 16,229 singletons born between January 2020 and December 2023 were included in this prospective study. Maternal depressive and anxiety symptoms in each trimester of pregnancy were assessed by Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7 scale, respectively. The neurodevelopmenta

SUBMITTER: Chen R 

PROVIDER: S-EPMC11876414 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature