The association between neighborhood environment, prenatal exposure to alcohol and tobacco, and structural brain development.

ABSTRACT: Prenatal alcohol and tobacco exposure affects child brain development. Less is known about how neighborhood environment (built, institutional, and social) may be associated with structural brain development and whether prenatal exposure to alcohol or tobacco may modify this relationship. The current study aimed to examine whether neighborhood environment is associated with brain volume at age 9-11, and whether prenatal exposure to alcohol or tobacco modifies this relationship. Baseline data from Adolescent Brain and Cognitive Development (ABCD) study was analyzed (N = 7,887). Neighborhood environment was characterized by 10 variables from the linked external dataset. Prenatal alcohol and tobacco exposures were dichotomized based on the developmental history questionnaire. Bilateral

SUBMITTER: Xia Y 

PROVIDER: S-EPMC11876420 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature