Mass cultivation of the dinoflagellate Alexandrium pacificum for gonyautoxin-1,4 production.

ABSTRACT: Bioactive venoms and toxins are emerging as a promising source of drug leads. Optimized through evolution, these compounds display remarkable selectivity and ligand affinity toward a range of relevant pharmacological targets. The successful development of new drugs from toxins is hampered in some areas by the chemical complexity of the active compounds, which limits the possibility of using chemical synthesis or recombinant strategies for drug lead generation. Marine paralytic shellfish toxins produced by marine microalgae is one such family of compounds. These compounds are highly potent blockers of voltage-gated ion channels, involved in regulating a range of physiological processes and thus versatile targets for drug development. To overcome the supply issue, the current paper describes

SUBMITTER: Greenhough H 

PROVIDER: S-EPMC11876455 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature