Nuclear translocation of CDK5RAP3 regulated by NXF3 promotes the progression of gastric cancer.

ABSTRACT:

Background

Nuclear-cytoplasmic transport proteins (NCTPs) impact the transport of proteins and RNA molecules between the nucleus and cytoplasm in tumor cells, making them promising targets for cancer therapy. Currently, the molecular mechanism and function of Nuclear RNA export factor 3 (NXF3) in gastric cancer (GC) remains unclear.

Methods

We used Univariate Cox regression analysis and LASSO regression analysis, Receiver Operating Characteristic (ROC) curves to construct and evaluate a NCTP prognosis risk scoring model (NCTP model). Moreover, we identified the key NCTP (NXF3) affecting GC through differential expression and prognosis analysis. Subsequently, we introduced NXF3 shRNA into GC cells to investigate the impact of NXF3 on the cell proliferation, cell migration, in

SUBMITTER: Zhang C 

PROVIDER: S-EPMC11876495 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature