Chemically Induced Senescence Prompts Functional Changes in Human Microglia-Like Cells.

ABSTRACT: In response to various stressors, cells can enter a state called cellular senescence which is characterized by irreversible cell cycle arrest and a senescence-associated secretory phenotype (SASP). The progressive accumulation of senescent glial cells in the central nervous system (CNS) with aging suggests a potential role for senescence as driver of aging and inflammation in the brain. As the main immune cell population residing in the CNS, microglia are thought to play a pivotal role in the progression of age-associated neuroinflammation. Furthermore, due to their slow turnover, microglia are highly susceptible to undergoing cellular senescence. However, current understanding of age-related changes in microglia and their impact on brain aging is limited. Due to the challenge in accessing

SUBMITTER: Armanville S 

PROVIDER: S-EPMC11876530 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature