Photothermally Responsive Hydrogel Releases Basic Fibroblast Growth Factor to Promote the Healing of Infected Wounds.

ABSTRACT: The treatment of infected wounds is often complicated by bacterial infection and impaired scar healing. Antibiotics and growth factors are typically utilized to address these clinical challenges and expedite wound healing. However, the use of hydrogels containing these therapeutic agents is often restricted to complex cases and increases treatment costs considerably. In this study, we developed a quaternized-chitosan-based hybrid hydrogel dressing (SQFB) with intrinsic antibacterial properties to address these limitations. The hybrid hydrogel contained interpenetrating polymer networks of basic fibroblast growth factor and black phosphorus nanosheets, facilitating a photothermal response that triggers the release of basic fibroblast growth factor upon near-infrared irradiation. In vitro ex

SUBMITTER: Ma S 

PROVIDER: S-EPMC11876544 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature